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- Y Combinator’s spring 2025 batch featured 70 startups focused on agentic AI.
- The intensive, three-month accelerator program invests $500,000 in each selected startup.
- BI combed through YC’s spring batch to find 10 of the most interesting AI agent startups.
Christmas came early for Y Combinator. The storied Silicon Valley accelerator had AI agents startups at the top of their wish list — and the startup community delivered.
When Y Combinator issued a callout earlier this year for more founders building so-called “agentic” AI — software that can essentially think and perform tasks on its own — entrepreneurs were all ears. Of the 144 companies in YC’s spring 2025 batch, 70 build agents, according to the accelerator’s startup directory. Many of the spring batch startups showed off their technology at YC’s Demo Day on Wednesday.
Each batch brings together a few hundred early-stage startups for a three-month sprint of product development and mentorship in San Francisco. Tens of thousands apply, and only a fraction make the cut. YC invests $500,000 in every company it selects, and its alumni roster includes success stories such as Stripe, Airbnb, DoorDash, Coinbase, and Instacart.
2025 marks the first time YC has run a spring cohort, which ran from April to June.
For its inaugural spring batch, YC partners said they were especially keen on startups exploring new and creative ways to harness artificial intelligence. Many of the startups that made the cut apply agentic AI across industries — from cybersecurity to consumer fintech to healthcare.
BI dug through YC’s Spring 2025 cohort to find 10 AI agent startups revolutionizing their respective industries. To represent the spread of startups in the overall cohort, we picked a handful of the many startups YC categorized as B2B, two healthcare startups, and one each of fintech, consumer, and industrials.
From technology that teaches old robots new tricks, to agents that help consumers apply for the best mortgage, here are some of the most exciting agentic startups in YC’s inaugural spring batch.
Aegis
What it does: Automates the insurance appeals process for healthcare providers to appeal and win denied health insurance claims
Year founded: 2025 in San Francisco by Krishang Todi, Aarav Bajaj, and Dhanya Shah
YC Partner: Aaron Epstein
Industries: Healthcare, Healthcare IT
Airweave
What it does: Turns a company’s productivity apps and tools into searchable databases for AI agents
Year founded: 2025 in San Francisco by Lennert Jansen and Rauf Akdemir
YC Partner: Aaron Epstein
Industries: B2B, Infrastructure
Approval AI
What it does: A co-pilot that automates the mortgage process, from rate shopping to negotiation to paperwork
Year founded: 2025 in San Francisco by Arjun Lalwani and Helly Shah
YC Partner: Pete Koomen
Industries: Fintech, Consumer Finance
Atlog
What it does: AI voice agents that conduct sales and payment calls for furniture rental companies
Year founded: 2024 by Vraj Parikh, John Bettinger, and Shaun Karakkattu
YC Partner: David Lieb
Industries: B2B, Operations
Beluga Labs
What it does: A Rippling for content creators that uses AI agents to organize income and expenses and analyze tax incentives
Year founded: 2024 in San Francisco by Fernando Young and Jack Swisher
YC Partner: Dalton Caldwell
Industries: B2B, Operations
Casco
What it does: Simulates attacks on a company’s AI agents and systems to discover vulnerabilities and find solutions
Year founded: 2025 by René Brandel and Ian Saultz
YC Partner: Dalton Caldwell
Industries: B2B, Security
Galen AI
What it does: Connects hundreds of healthcare records and fitness tracker data into information an AI agent can use to offer personalized health and wellness advice
Year founded: 2025 by Viraj Mehta and Priyanka Shrestha
YC Partner: Dalton Caldwell
Industries: Healthcare, Consumer health and wellness
Mbodi AI
What it does: Teach existing robots new skills using natural language and AI agents
Year founded: 2025 in New York by Xavier (Tianhao) Chi and Sebastian Peralta
YC Partner: Pete Koomen
Industries: Industrials, Manufacturing and robotics
Plexe
What it does: Builds open-source agents that build predictive machine-learning models from natural language prompts
Year founded: 2025 in San Francisco by Vaibhav Dubey and Marcello De Bernardi
YC Partner: Nicolas Dessaigne
Industries: B2B, engineering, product, and design
Willow
What it does: A voice dictation app that replaces the keyword with spoken word and uses an AI agent to craft messages in a user’s tone.
Year founded: 2025 in Palo Alto by Allan Guo and Lawrence Liu
YC Partner: Nicolas Dessaigne
Industries: Consumer
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